Estimated timing of the last common ancestor of the SARS coronavirus.
نویسندگان
چکیده
منابع مشابه
Date of origin of the SARS coronavirus strains
BACKGROUND A new respiratory infectious epidemic, severe acute respiratory syndrome (SARS), broke out and spread throughout the world. By now the putative pathogen of SARS has been identified as a new coronavirus, a single positive-strand RNA virus. RNA viruses commonly have a high rate of genetic mutation. It is therefore important to know the mutation rate of the SARS coronavirus as it spread...
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The drastic increase in the number of coronaviruses discovered and coronavirus genomes being sequenced have given us an unprecedented opportunity to perform genomics and bioinformatics analysis on this family of viruses. Coronaviruses possess the largest genomes (26.4 to 31.7 kb) among all known RNA viruses, with G + C contents varying from 32% to 43%. Variable numbers of small ORFs are present...
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The ongoing outbreak of COVID-19 that began in Wuhan, China, has constituted a Public Health Emergency of International Concern, and spread all over the world. In a phylogenetic network analysis of human severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) genomes, three central variants were distinguished by amino acid changes, which named A, B, and C; with A being the ancestral type a...
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SARS-CoV-2 is a member of the coronaviruses family that causes the outbreak of coronavirus disease 2019 (COVID-19) in China in late 2019 which has exploded to a global pandemic. The reference genome of the SARS-CoV-2 is considered to be very closely related to SARS-CoV and the virus uses the ACE-2 receptor for cellular entry similar to SARS-CoV. The most common symptoms of COVID-19 are fever, c...
متن کاملIntraspecies diversity of SARS-like coronaviruses in Rhinolophus sinicus and its implications for the origin of SARS coronaviruses in humans.
The Chinese rufous horseshoe bat (Rhinolophus sinicus) has been suggested to carry the direct ancestor of severe acute respiratory syndrome (SARS) coronavirus (SCoV), and the diversity of SARS-like CoVs (SLCoV) within this Rhinolophus species is therefore worth investigating. Here, we demonstrate the remarkable diversity of SLCoVs in R. sinicus and identify a strain with the same pattern of phy...
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ورودعنوان ژورنال:
- The New England journal of medicine
دوره 349 25 شماره
صفحات -
تاریخ انتشار 2003